In women, high leptin and obesity can boost the chances of breast cancer.Leptin-related inflammatory “cytokines” send signals that seem to impact how breast cancer cells grow and stay alive.

Anil Oza is STAT’s 2024-2025 Sharon Begley Science Reporting Fellow. You can reach Anil on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare. Scientists hoped ...

For the girl (a carrier of leptin variant G59S), the dose was increased to 0.15 mg/kg on day 2 of treatment, and tapered down starting on day 264, with an ending dose of 0.07 mg/kg.

Disappointing clinical trials halted progress in using leptin for the treatment of obesity. Here, the authors propose a role for leptin in the treatment of type 1 diabetes and postulate that if ...

Leptin levels tend to peak between midnight and dawn, making you less hungry. That makes sense because there’s not much you can do about being hungry when you’re asleep in the middle of the night.

Leptin, produced primarily by fat cells, typically signals the brain when enough food has been consumed, helping to regulate energy and appetite. But in some individuals with obesity, ...

Leptin is a hormone that helps signal to your brain when you're satiated or hungry. However, leptin resistance may block this signal and increase your risk of obesity. Learn more about leptin and ...

Leptin is the satiating hormone. It is naturally secreted by your fat cells to suppress appetite; it's your brain's cue to stop eating. When there's a leptin deficiency, ...

Ghrelin and leptin are two hormones that are of great interest in appetite regulation. Leptin is commonly considered anorexigenic (i.e., appetite suppressant), while ghrelin is orexigenic (i.e ...

The authors developed an assay using optogenetic stimulation of dopaminergic neurons as a reference stimulus to measure the reward value of nutrients. They found that fasting increases and leptin ...

The new study shows that leptin toggles a runner’s desire by cutting access to a reward chemical — dopamine — in one of the brain’s motivation centers, the ventral tegmental area.