Scientists have developed a hydrogel “rest stop” that shields cancer-fighting T cells, delaying their exhaustion and boosting ...

The SPECIFIC framework not only provides new tools for studying T cell exhaustion but also establishes a generalizable approach for engineering cell state-responsive synthetic promoters.

The secret lies in targeted supplements like creatine monohydrate that amplify strength and muscle volume, and BCAAs that slash soreness and jumpstart repair. Pre-workout blends ignite focus and ...

T-cell exhaustion and pre-existing T-cell immunity in circulation as predictive biomarkers for immunotherapy in NSCLC patients.. If you have the appropriate software installed, you can download ...

Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced (armore ...

Lactic acid has long been villainized, but new research shows it doesn't impair muscle function. In fact, it might actually ...

In this case, your body’s cells resort to breaking down carbohydrate stores for energy. Lactic acid – or, to use the physiologically accurate term, lactate – is produced as a result.

By giving T cells more energy, the team is hopeful that they might be less susceptible to exhaustion, improving current immunotherapies. T-cell exhaustion is driven by mitochondrial loss and ...

"Off the shelf" CAR T-cell therapies could offer a solution in chronic lymphocytic leukemia, where T-cell exhaustion creates treatment challenges.

Methods: In our present study, single-cell RNA-seq data for OS from the GEO database was analysed to identify CD8+ T cells and discern CD8+ T cell subsets objectively. Subgroup differentiation ...

T cell exhaustion results in reduced cytokine production, weakened cell proliferation potential, and an altered transcriptional program and epigenetic landscape. By understanding T cell exhaustion ...