A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

that targets lysine-specific demethylase 1 (LSD1 or KDM1A), an enzyme crucial for cancer stem and progenitor cells, particularly in abnormal bone marrow cells. Bomedemstat is currently being ...

Credit: MPE “If you look at the distribution of the galaxy clusters in the sky in a spherical shell with a distance of 416 to 826 million light-years, you immediately notice a huge structure that ...

It was subsequently found to drive degradation of subunits in a transcriptional repressor complex ‘LHC’, comprised of the histone demethylase LSD1 ... A cryo-EM structure of UM171 associated ...

It interacts with LSD1, impacts gene expression ... Epigenetic modifications have a crucial function in regulating gene expression and chromatin structure, which can have a direct or indirect impact ...

While a direct targeting of the partial loss-of-function or change in function observed in these factors is very difficult to imagine, recent data suggests that the inhibition of LSD1, an important ...

Investopedia / Yurle Villegas An organizational chart, or org chart, graphically represents an organization's structure by detailing the roles, responsibilities, and relationships between ...

Here we report that RIOK1 is methylated at K411 by SETD7 methyltransferase and that lysine-specific demethylase 1 (LSD1) reverses its methylation. The mutated RIOK1 (K411R) that cannot be methylated ...