Plant phototropism—directional growth in response to light—serves as a key adaptive mechanism, optimizing photosynthesis and ...

The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular ...

Thus, future phosphorylation studies should be targeted at not only definitively linking a phosphorylation event to its cognate kinase in vivo, but also mapping more time- and condition-specific ...

Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers. Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome amplification, chromosome ...

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, ... the HIPK2 deficiency and apoptosis signaling acted via decreased ERK1/2 kinase phosphorylation.

In a search for the kinase responsible for PDK1 Y163 phosphorylation, TIE1 was identified as a potential candidate. TIE1, a receptor tyrosine kinase, was found to be upregulated by ING5 and ...

Thus, the identification of CDK phosphorylation targets (substrates) is an important goal in the search for cancer therapeutics. However, despite many advances, identifying protein kinase substrates ...

Next-generation protein kinase inhibitors have the potential to revolutionize cancer therapy. Clinical trials have already shown extremely promising results, with next-generation inhibitors ...