This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other ...

Necroptosis is the predominant form of neuronal death after ischemic stroke. This study identifies the deubiquitinating ...

The scaffold protein JIP1 plays a key role in the c-Jun N-terminal kinase (JNK) signaling pathway by facilitating the colocalization of multiple kinases, thereby ensuring their precise and efficient ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

The FDA has approved ensartinib in adult patients with anaplastic lymphoma kinase (ALK)–positive locally advanced or metastatic non–small cell lung cancer (NSCLC) naive to ALK treatment.

Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China ...

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single canonical MAST kinase family member KIN-4 is shown to fulfill this role and ...

These compounds have activities as receptor-interacting protein kinase 1 (RIPK1) inhibitors and may potentially ... The inventors used the following three assays to test the compounds of formula 1: ...

Molecular modeling shows specific structural differences between the kinase domains of ROS1 and ALK that explain ... the crizotinib-resistant CD74-ROS1 G2032R mutant in cell-based assays (23). In ...

The conformation of the ATM kinase domain is most similar to the inactive states ... We evaluate the importance of these structural findings with mutagenesis and biochemical assays. This manuscript is ...

This paper examines the mechanism of signal transmission through the histidine kinase PhoQ. The paper nicely describes a model of signaling by allosteric coupling between individual domains rather ...