Here we review hypotheses for the mechanism of action of ketamine as an antidepressant, including synaptic or GluN2B-selective extra-synaptic N-methyl-D-aspartate receptor (NMDAR) inhibition ...

Scientists from Sweden’s Karolinska Institutet have discovered a new mechanism to help illustrate the rapid antidepressant qualities of ketamine. The large study imaged patients with treatment ...

Based on these data, we propose that ketamine, and individually (S)-ketamine and (R)-ketamine enantiomers, exert NMDA receptor inhibition-independent antidepressant actions via metabolism to their ...

Looking closer, the researchers found a mechanism that could explain why ... ‘‘The consequence of this dual action of ketamine is that it does not induce the synaptic plasticity that addictive ...

When scientists tried to clarify ketamine’s mechanism of action in previous studies ... But since ketamine’s effect persists long after it leaves the body, its action could not be explained by mere ...

Understanding the mechanism of ketamine’s action, and its involved signaling pathways, is crucial for the development of new treatment options for depression. Chen and his team validated their ...

Psychedelics such as ketamine, psilocybin ... and Song et al presents the first comprehensive mechanism explaining how various psychedelics, each interacting with different combinations of ...

Unlike traditional antidepressants that focus on serotonin or norepinephrine, ketamine's action on glutamate pathways may explain its remarkably rapid effects, often within hours rather than weeks." ...