Isoniazid (INH) remains a cornerstone key constitute of the current tuberculosis management strategy, but its hepatotoxic potentiality remains a significant clinical problem. Our previous findings ...

Only a small number were not tested due to being unreachable or refusing the test. Despite these challenges, the response to prophylaxis with isoniazid (INH) and rifapentine (RPT) was promising, as ...

Aims: To define the pharmacokinetics of isoniazid (INH) in children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype. Methods: The first order elimination rate constant ( k ) ...

DISCUSSION The study assumed that a 20% difference in the plasma concentration of INH between sexes could alter the exposure to the drug, considering a mean concentration of 3.25 µg/mL isoniazid, a ...

Mtb is known for its ability to resist drugs and evade the human immune system. Additionally, multidrug-resistant bacteria have emerged that are resistant to the two most potent TB drugs, isoniazid ...

Methods A cohort analysis was done within a prospective, double-blinded, placebo-controlled trial of isoniazid (INH) compared with placebo in children infected with HIV in Cape Town, South Africa, a ...

Latent TB is typically treated with the antibiotic isoniazid (INH) "taken as a single daily pill for six to nine months," ...

A new study has found that a novel functional C1-INH (fC1-INH) dried blood spot (fC1-INH DBS) assay for hereditary angioedema (HAE) has similar sensitivity and specificity as conventional testing and ...

Effect on Mean Serum Isoniazid (INH) Bioassay Levels of Raising the Test Dose from 4 to 8 Mg. per Kilogram of Body Weight and of Adding Para-aminosalicylic Acid (PAS) in 46 Patients.

Indian scientists from the Institute of Nano Science and Technology in Mohali have developed a groundbreaking nose-to-brain drug delivery method for treating Central Nervous System Tuberculosis ...

“The study further employed a targeted metabolomics approach using UPLC/QToF-MS to detect and quantify intracellular isoniazid (INH) in a complex biological matrix of bacteria which showed that SVE ...

New Delhi: Through a recent notice, after considering the Wholesale Price Index (WPI) at 0.00551% for the year 2024, the National Pharmaceutical Pricing Authority (NPPA) has revised the ceiling price ...