A 3D paper-based analytical device (3D-osPAD) with in situ gold signal amplification enables one-step, highly sensitive ...

In clinical validation, the ASTRA device outperformed the widely used interferon-gamma release assay (IGRA), which depends on the patient’s CD4+ T cells to produce interferon-gamma (IFNγ).

When tested against the traditional IGRA blood test (Interferon-Gamma Release Assay), the ASTRA detected TB in HIV-infected individuals with 87% specificity compared to IGRA’s 60%, while also ...

Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in ...

Introduction In Hong Kong, tuberculin skin test (TST) with a 15 mm cut-off was used at 0 and 3 months for contact screening, but half of future tuberculosis cases might be missed. Follow-on interferon ...

Interferon gamma release assay should be preferred over tuberculin skin test, where available. Hepatitis B (HBV) antiviral treatment should be guided by HBV status defined prior to starting ...

The interferon-gamma release assays (IGRAs) quantifies (in vitro) the cellular immune response of T lymphocytes to specific M. tuberculosis antigens by detecting the interferon-gamma cytokine (IFN-γ) ...

Interferon-gamma release assays (IGRA) are blood tests used to identify people with TB infection. IGRA tests cannot discriminate between latent and active TB. Furthermore, false negatives can occur in ...

Aggarwal, A.N., Agarwal, R., Gupta, D., Dhooria, S. and Behera, D. (2015) Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis A Systematic Review ...

It is not known whether using a host blood transcriptomic signature in combination with an interferon gamma release assay, such as QuantiFERON-TB Gold-plus (QFTPlus), might improve discriminatory ...

Trajman, A., Steffen, R.E. and Menzies, D. (2013) Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection An Overview of the Evidence.