However, some proteins can bypass this system using unconventional mechanisms, including direct translocation across the plasma membrane, transporter-mediated secretion, and intracellular ...

However, some proteins can bypass this system using unconventional mechanisms, including direct translocation across the plasma membrane, transporter-mediated secretion, and intracellular vesicle ...

A newly discovered mechanism that leads to liver dysfunction ... hasn't improved outcomes in conditions like obesity, insulin resistance, and cardiovascular disease. The new study shifts the ...

However, some proteins can bypass this system using unconventional mechanisms, including direct translocation across the plasma membrane, transporter-mediated secretion, and intracellular vesicle ...

Unconventional protein secretion mechanisms represent a significant deviation from the classical endoplasmic reticulum–Golgi pathway. These alternative routes enable proteins—often lacking a ...

In other patients, it is associated with nondiabetic insulin resistance and probably precedes type 2 diabetes. In obesity and insulin resistance, increased secretion of proinflammatory cytokines ...

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States ...

Expert Rev Endocrinol Metab. 2008;3(2):147-159. The inter-relationships between insulin resistance and β-cell dysfunction have been elegantly described in Weir and Weir's five-stage model of the ...