Macrophages are implicated in the pathogenesis of obesity, yet the underlying mechanisms remain incompletely understood. Here ...

Pulmonary fibrosis: Nerandomilast inhibits phosphodiesterase 4B, may treat multiple forms of disease by Catholic University of the Sacred Heart edited by Stephanie Baum, reviewed by Andrew Zinin ...

Drug combination inhibits genes that drive aggressive pancreatic cancer, study finds by HonorHealth Research Institute ...

Adiponectin levels were associated with increased likelihood of metabolic health improvements and lower risk for diabetes across 6 years.

Adiponectin is a positive cytokine released by adipocytes and endothelial cells, known to induce liver-, cardio-, and neuro-protective effects. We evaluated the potential role of adiponectin as the ...

IL-6 treatment inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes. [75] Through its ability to inhibit TNF-α, adiponectin indirectly inhibits CRP and IL-6.

CONCLUSION These results provide first evidence that adiponectin overexpression significantly inhibits AngII-induced AAA formation in LDLR -/- mice. The protective actions of adiponectin appear to be ...

Adiponectin, a hormone secreted by adipose tissue, plays a doubly important role in preserving pancreatic function: in lean people, it protects beta cells, which make insulin, and in obese people ...

Activation of adiponectin receptors in young and aged mice induces changes in muscular metabolism via stimulation of AMPK and PGC-1a and ameliorates age-related muscle loss of function.

Adipose tissue can more than double in mass and then return to baseline. This review discusses the functional roles of human white and brown adipose tissue and its excess in obesity, as well as its ...

Adiponectin inhibited PA-mediated NLRP3 inflammasome activation in hepatocytes. Adiponectin analogs or AMPK agonists could serve as a potential novel agent for preventing or delaying the progression ...

Editorial on the Research Topic Adiponectin: Friend or Foe? Toward Understanding the Complexities of Adiponectin Biology and Challenges in Pharmaceutical Development This topic collection focuses on ...