Macrophages and other immune cells are the natural frontline immune warriors of our body, defending the body against invading ...

As the authors reported in Radiology Case Reports, the patient had no history of cancer and had no pain, weakness, numbness, ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Each immunoglobulin consists of two long protein chains called heavy chains, which are bound to two short protein chains called light chains. When a person has MM, the atypical plasma cells make ...

Care of patients with systemic immunoglobulin light chain (AL) amyloidosis has undergone transformative changes, leading to marked, steady progress in outcomes for patients over the past four decades.

Histopathology of intraoral lesions revealed hematic extravasation and λ light chain deposition on the capillary endothelium. A hematologist performed a bone marrow biopsy, which was diagnostic for ...

Evidence from RCTs shows that IVIg improves disability for at least two to six weeks compared with placebo, with an NNTB of 4. During this period, IVIg probably has similar efficacy to oral ...

Your doctor names your myeloma after the type of: abnormal immunoglobulin (paraprotein) it is making (G, A, D, E or M) light chain (kappa or lambda) Based on this your doctor might say you have, for ...

Immunoglobulin (Ig) molecules are "Y" shaped glycoproteins that consist of two heavy and two light chains. The light chains are made up of two domains, and the heavy ones are made up of four.

Light chain multiple myeloma is a subtype of multiple ... The type depends on the immunoglobulin that a myeloma cell produces, also known as antibodies or M-proteins. According to the ...