Seven‐day‐old Wistar rat pups were exposed to hypoxia–ischemia, followed by melatonin or vehicle treatment. Detailed analysis of the AMPK/mTOR/autophagy pathway, short‐ and long‐term neuroprotection, ...

The AMPK/mTOR signaling pathway was detected by western blotting. EB alleviated hypobaric hypoxia-induced pulmonary edema, hypoxemia, acid-base imbalance in the blood, inflammation, and oxidative ...

High-altitude pulmonary edema (HAPE) is a life-threatening disease, and autophagy deficiency is implicated in the pathogenesis of HAPE. Eleutheroside B (EB), which is the main bioactive component of ...

AMPK has a key role in PH, either during the early process of hypoxic pulmonary vasoconstriction or later during pulmonary vasculature remodeling, or both. However, whether AMPK activation or ...

Hypoxia-inducible factor-1α (HIF-1α), ... AMPK is used as a sensor of cell energy metabolism. The study found that the inhibition of MIF caused the decrease of p-AMPKα, accompanied by the decrease of ...

STOCKHOLM, Aug. 17, 2020 /PRNewswire/ -- In previous Phase I and Phase IIa clinical trials in healthy subjects and in type 2 diabetics, the small molecule AMPK activator compound O304 was administered ...

Endothelial AMP-activated protein kinase (AMPK) deletion accelerates hypoxia-induced pulmonary hypertension. A, Representative Elastica–Masson (EM) and immunostaining for α-smooth muscle actin (α-SMA) ...

Adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric serine-threonine kinase important as a metabolic sensor for intracellular ATP levels and plays a key role in regulating cell ...

Adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric serine-threonine kinase important as a metabolic sensor for intracellular ATP levels and plays a key role in regulating cell ...

Hypoxia-induced AMPK activation was also blunted in heart muscles by preincubation with either anti–sauvagine-30, a neutralizing anti-Ucn2 antibody, or εV1-2. Treatment with Ucn2 in vivo augmented ...

DJ-1 influences AMPK expression and autophagy during hypoxia. (A) Decreased AMPK phosphorylation. U2OS cells were transfected with control (si-Sc) or DJ-1 (siDJ-1) siRNA and treated 48 h later with ...