The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

New AMPK Program Targets Aging and Muscle Regeneration In addition to its lead candidates, Biolexis will continue development of BLX-08155, an isoform-specific AMPK activator identified for its ...

Is AMPK a central mediator of insulin-independent glucose transport, which enables fuel-depleted muscle cells to take up glucose for ATP regeneration?

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

Repeated sprint ability (RSA) is a critical success factor for intermittent sport performance. Repeated sprint training has been shown to improve RSA, we hypothesised that hypoxia would augment these ...

Abstract. Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age. Chronic mild hypoxia (CMH; 8% O 2) triggers transient blood-brain barrier (BBB) disruption, an ...

Zanthoxylum seed powder contains dominant α-linolenic acid (ALA). Its regulatory mechanism as a novel feed additive for the livestock field is not clear. In this study, RNA-seq was used to identify ...

Extracellular matrix (ECM) stiffness is a key stimulus affecting cellular differentiation, and osteoblasts are also in a three-dimensional (3D) stiff environment during the formation of bone tissues.

Here we demonstrate that ROS activate two proteins, AMP-activated kinase (AMPK) and hypoxia-inducible factor 1 (HIF-1), to promote longevity by increasing immunity. Further, we find that internal ROS ...

Our study identifies hypoxia-driven histone lactylation as a potential target to block immunosuppressive neutrophils and boost the effects of immunotherapy in glioblastoma and in other cancer settings ...