Small-molecule irreversible tyrosine kinase inhibitors as high potent agents have led to improvements in disease-free and overall survival in patients with HER2-amplified cancer. The approved ...

Signal transducer and activator of transcription factors (STATs) are proteins that can translocate into the nucleus, bind DNA, and activate gene transcription. STAT proteins play a crucial role in ...

Within that partnership, SunRock agreed to develop ADCs for cancer using Debiopharm's linker technologies, including for tumors expressing HER2 and HER3. The firms signed a new partnership agreement ...

Breast cancer is one of the most common cancers globally,6 with HR+/HER2- being the most prevalent subtype, accounting for approximately 70% of cases.7,8,9 Over 40% of HR+/HER2- breast cancer cases ...

The de-escalation of therapy helps avoid unnecessary toxicity from treatment, making it an important consideration during the treatment of patients with brain cancer or metastases, Dr. Manmeet Singh ...

Ipatasertib plus with fulvestrant (Faslodex) led to significantly longer progression-free survival (PFS) compared with placebo and fulvestrant in patients with estrogen receptor (ER)-positive, ...