The nature of HER2 dimerization can vary significantly across different cancer types. In breast cancer, HER2 frequently forms heterodimers with HER3, and the HER2/HER3 heterodimer is highly potent ...

SAN DIEGO, CA, USA I June 03, 2025 I Avenzo Therapeutics, Inc. (“Avenzo”), a clinical-stage biotechnology company developing next-generation oncology therapies, today announced initiation of a Phase 1 ...

The de-escalation of therapy helps avoid unnecessary toxicity from treatment, making it an important consideration during the treatment of patients with brain cancer or metastases, Dr. Manmeet Singh ...

HER2 mutations have also been identified as potential oncogenic drivers in lung cancer and occur in up to 4% of NSCLC. 2,3 In the past two decades, several clinical trials have investigated the ...

Cell surface receptors, such as the G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK), play central roles signalling pathways. Due to their central role in regulating a wide range ...