New research has, for the first time, discovered hemoglobin in the uppermost layer of human skin, and found that it helps protect against damage. The findings provide important insights into skin ...

Hemoglobin Barts disease Sometimes, a fetus may inherit problems with all four alpha globin genes. This extremely severe form of alpha-thalassemia disease is called hemoglobin Barts disease.

Do people with thalassemia trait have symptoms or need treatment? We discuss this and other concerns for carriers of the thalassemia gene.

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed instead of beta-globin during fetal development. Gamma-globin combines with alpha-globin to form HbF.