Human papillomaviruses, or HPVs, can cause dangerous infections in the skin and mucous membranes and may lead to cancer.

Human papillomaviruses, or HPVs, can cause dangerous infections in the skin and mucous membranes and may lead to cancer.

Scientists have identified dozens of human proteins that SARS-CoV-2, the virus that causes COVID-19, depends on to replicate ...

As HPV capsid protein expression has a requirement for SR protein activity, exploration of the applicability of IDCs to inhibit the HPV replication cycle may open up new avenues in HPV antiviral ...

Disclosures Future Microbiol. 2010;5 (10):1493-1506. 0 HPV Replication & Epithelial Differentiation The replication cycle of HPV is tightly linked to differentiation of the epithelium it infects.

The papillomaviruses do not follow once‐per‐cell cycle replication mode (Ravnan et al, 1992; Piirsoo et al, 1996); therefore, multiple unscheduled initiation events at the functional integrated HPV ...

Human viral oncogenesis is a complex phenomenon and a major contributor to the global cancer burden. Several recent findings revealed cellular and molecular pathways that promote the development and ...

Expression of viral life cycle markers E4 and L1 proteins was also verified in each batch of NIKS16 or NIKS18 cells to ensure they supported HPV replication. 28 NIKS16 and NIKS 18 cell lines were used ...

However, when the HPV replication cycle is switched to the late stage, p670 mediates only late gene expression, including L1, L1i, and L2. All the early mRNAs produced by promoter p97 and p670 are ...

Since differentiation of stratified epithelia is essential for the productive HPV replication cycle (Roden and Stern, 2018), and due to the species specificity of papillomaviruses, it has been ...

Regarding cell cycle distribution, adavosertib induced an accumulation of cells in the S-phase, indicative of replication stress, while olaparib had little effect on its own or when added to Wee1 ...