According to the Kenya Prevention Revolution Road map, Kisii County has a HIV prevalence of 8%. It is estimated that 63,715 people are living with HIV of which 7,715 are children.

Around 1.4 million people have HIV in Kenya, according to UNAIDS data in 2022. ... raised the alarm that HIV infection rates among those ages 15 to 29 had surged by 61% between 2021 and 2022. ...