A research led by the IBB-UAB has managed to decypher the structure of the human protease SENP5, implicated in ...

Whether antiretroviral therapy (ART) is always completely suppressive, or HIV might continue to replicate at low levels despite ART in some people with HIV (PWH), is still debated. Here, we ...

Modifications in proteins after they are synthesized (post-translational) are changes that play a fundamental role in cell ...

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

The Trump administration's plan to cut funding for HIV vaccine research comes at a time when the field is making substantial ...

The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein, but also removes ...

Crystallographic studies of HIV protease−inhibitor complexes help explain the perhaps surprisingly high degree of substituent additivity in this system, and allow some of the additivity coefficients ...

Underscoring the global nature of HIV vaccine research, scientists with the CHAVD program helped design some of the immunogens, Bekker says. Then, the team would "put these immunogens into humans, in ...

This article is cited by 28 publications. Oksana Gerlits, David A. Keen, Matthew P. Blakeley, John M. Louis, Irene T. Weber, and Andrey Kovalevsky. Room Temperature Neutron Crystallography of Drug ...

Since the first case of HIV in the U.S. nearly 44 years ago, the country has made significant progress towards eradicating the disease. Now on the cusp of ending the epidemic, roadblocks from ...

Older adults with HIV are encountering health management challenges as they age, despite achieving stable HIV treatment, according to new research from South Korea examining the experiences of ...

After the Trump administration cut billions in foreign aid, two African countries that succeeded in curbing the spread of HIV are now in danger of backsliding. Click here to read Jon Cohen's article ...