HIV-1 protease inhibitors (PIs) have long been central to antiretroviral therapy, directly targeting the enzyme responsible for processing viral polyproteins into functional units.

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

Modifications in proteins after they are synthesized (post-translational) are changes that play a fundamental role in cell ...

A research led by the IBB-UAB has managed to decypher the structure of the human protease SENP5, implicated in ...

The Trump administration's plan to cut funding for HIV vaccine research comes at a time when the field is making substantial ...

Whether antiretroviral therapy (ART) is always completely suppressive, or HIV might continue to replicate at low levels despite ART in some people with HIV (PWH), is still debated. Here, we ...

What to know about the Trump administration's move to cut HIV vaccine research funding 02:33. The Trump administration has moved to end funding for a broad swath of HIV vaccine research, saying ...

While Domingo claimed the rise of HIV cases could have been caused by easier access to sex via social media and dating apps, Mata said the true cause was the youth’s lack of HIV protection. “Sa buong ...

Updated at 3:38 p.m. ET on May 31, 2025. Solving HIV vaccination—a puzzle that scientists have been tackling for decades without success—could be like cracking the code to a safe.

Of 49 countries surveyed in a recent analysis, 15 have historically relied on the the U.S. for most of the funding for their HIV/AIDS responses. That funding is largely gone now.

Since the first case of HIV in the U.S. nearly 44 years ago, the country has made significant progress towards eradicating the disease. Now on the cusp of ending the epidemic, roadblocks from ...