This online short course that will look at synthetic and scale up aspects of making and using Grignard reagents. The course will be in two sections of 60-90 minutes held over two consecutive days as ...

The Horner–Wadsworth–Emmons (HWE) reaction is a fundamental reaction in organic chemistry, widely used to create conjugated carbonyl compounds. Conjugated carbonyl compounds are used in many ...

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Aromatic ketones have long been valuable intermediates in chemical synthesis, particularly in cross-coupling reactions where different chemical entities are combined to form new compounds. For ...

Rina Namioka, Minori Suzuki, Suguru Yoshida. Synthesis of 1,2,3-triazoles using Grignard reactions through the protection of azides. Frontiers in Chemistry, 2023; 11 DOI: 10.3389/fchem.2023.1237878 ...

The reactive complex in the Grignard reaction involves two molecules from the Grignard reagent, which interact with acetaldehyde – CH3CHO – and three tetrahydrofuran molecules - (CH2)4O. Other solvent ...

This is a scientific breakthrough which provides important insights into basic mechanisms of allergic reactions and may pave the way for more effective allergy medicine.

But even though the reaction was first described 120 years ago, chemists have only now uncovered the details of its complex mechanism (J. Am. Chem. Soc. 2020, DOI: 10.1021/jacs.9b11829) ...