Gen X and millennials three times more likely to be diagnosed with appendix cancer than their parents, study finds ...

They are mapping out interactions between tumour cells and the nerve cells surrounding them – and shattering the long-held belief that these are of little significance.

We conducted a phase 1b–2 multicenter study of obe-cel in adults (≥18 years of age) with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). The main cohort, cohort 2A, included ...

In a recent study, researchers at the University of California, San Diego, have provided new insights into the central role of goblet cells—specialized cells that line the gut—in maintaining a ...

Researchers at UC San Diego have examined the critical role of goblet cells in gut immunity and health. GCs create a mucus barrier that protects against pathogens while supporting beneficial ...

In a recent study, researchers at the University of California, San Diego, have provided new insights into the central role of goblet cells - specialized cells that line the gut - in maintaining a ...

Rab7-mediated changes in goblet cell function play a crucial role in triggering gut inflammation during colitis.

Goblet cell adenocarcinoma (GCA), formerly termed goblet cell carcinoid, accounts for 14% of primary neoplasms of the appendix (10) and has demonstrated an incidence of 0.05-0.3 per 100,000 per year ...

Intestinal stem cells and transit-amplifying (TA) cells proliferate and give rise to different specialized cells committed to either absorptive or secretory lineage, represented by the two major cell ...

The regulation of unfolded protein response (UPR) sensors has been studied for over 20 years, but IRE1β has remained a mystery. IRE1β is highly expressed in goblet cells: specialized epithelial cells ...

Background: Appendix goblet cell adenocarcinomas (GCA) are rare aggressive tumours with patients often presenting with peritoneal metastases. Cytoreductive surgery and heated intraperitoneal ...

GOBLET is an open-label, non-randomized, multiple-cohort, phase 1/2 study evaluating evaluate the safety and efficacy of pelareorep combined with atezolizumab in patients with metastatic pancreatic, ...