One of the biggest challenges facing biologic drug developers are varying efficacy and the dangers of side effects.

Chinese hamster ovary (CHO) cells are the cornerstone of biopharmaceutical production, accounting for 70% of all approved recombinant protein production. These immortalized cells offer high ...

When the researchers knocked out this gene circuit, the CHO cells stopped producing lactic acid. Moreover, the cells demonstrated improved growth and, compared to similarly treated controls ...

Chinese hamster ovary (CHO) cells are the most widely used cells for producing ... readily facilitate activating silent genes by CRISPRa to obtain more human-like glycosylation. Together, we envision ...

generated in Chinese Hamster Ovary (CHO) cells and deficient in N-linked glycosylation sites vital for binding several families of anti-HIV broadly neutralizing antibodies (bN-mAbs). Researchers ...

Chinese Hamster ovary (CHO) cells, however, have since become the preferred hosts for production due to their increased productivity, ease of use, and stability. Differences between murine and hamster ...

such as CHO cells and mastocytoma cells, a tumorigenic variant of mast cells. To alter the glycosylation patterns of heparan sulfates, it is necessary to engineer their multi-enzyme biosynthetic ...

Significantly, the post-translational modifications (such as glycosylation) and folding of human proteins are more closely conserved when proteins are processed by CHO cells. A more recent ...