Modified Fluorouracil, Leucovorin, Irinotecan, and Oxaliplatin or S-1, Irinotecan, and Oxaliplatin Versus Nab-Paclitaxel + Gemcitabine in Metastatic or Recurrent Pancreatic Cancer (GENERATE, JCOG1611) ...

Abstract: Inductive bias in machine learning (ML) is the set of assumptions describing how a model makes predictions. Different ML-based methods for protein-ligand binding affinity (PLA) prediction ...

(RTTNews) - Ligand Pharmaceuticals Inc. (LGND) has announced the pricing of $400 million aggregate principal amount of 0.75% convertible senior notes due 2030 in a private placement. The company also ...

Ligand Pharmaceuticals (NASDAQ:LGND) has priced $400 million in 0.75% convertible senior notes due 2030 in a private placement to qualified institutional buyers. Buyers have a 13-day option to ...

Orchestra BioMed reported that it has secured over $111 million in financing through a series of transactions and offerings—supported by deals with Medtronic and Ligand Pharmaceuticals—as it looks to ...

Orchestra BioMed (Nasdaq:OBIO) announced today that it completed strategic transactions and equity offerings worth an expected $111.2 million. The company raised the gross proceeds through strategic ...

JUPITER, Fla., July 10, 2025 (GLOBE NEWSWIRE) -- Ligand Pharmaceuticals Incorporated (Nasdaq: LGND) today announced that its partner Pelthos Therapeutics Inc. (NYSE American: PTHS) has commercially ...

The work presents a valuable extension of qFit-ligand, a computational method for modeling conformational heterogeneity of ligands in X-ray crystallography and cryo-EM density maps. The authors ...

Which converter(s) do you recommend for generating SMILES strings that contain correct stereochemical information from 3D ligand files in SDF, MOL2, or PDB ligand files? I have some difficult ligand ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. In this study, we addressed the challenge of estimating binding free energies in ...