In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...

More than 90% of patients achieved clinically meaningful weight reduction compared to placebo in a phase 3 trial of ecnoglutide.

A diabetes medication that lowers brain fluid pressure has cut monthly migraine days by more than half, according to a new ...

Semaglutide, a synthetic analog of glucagon-like peptide-1 (GLP-1), has garnered attention for its intriguing properties and potential implications in various r ...

They exert multiple physiological effects by activating the glucagon-like peptide-1 receptor (GLP-1R) and its downstream signaling pathways, including enhancing insulin secretion, suppressing appetite ...

Furthermore, glucagon signaling was identified as the top-ranked signaling pathway affected in the cardiomyocytes associated with HFpEF. Treatment with a glucagon receptor antagonist significantly ...

Guo: Because glucagon increases the production of glucose ... and the p38α-FOXO1 signaling pathway is a potential therapeutic target for the treatment of type 2 diabetes. Specifically, inhibiting ...

Guo: Because glucagon increases the production of glucose in the liver ... p38α MAPK is a major player in regulating glucose levels, and the p38α-FOXO1 signaling pathway is a potential therapeutic ...

In a study of mice, researchers worked out a neural pathway that could help researchers ... of a mystery how the brain gets the alarm signal, then sends another one to tell the stomach to initiate ...

by interfering with the intracellular location and signaling pathways of glucagon receptor, thereby reviving glucagon antagonism as potential treatment for type 2 diabetes. Need for novel ...