More than 90% of patients achieved clinically meaningful weight reduction compared to placebo in a phase 3 trial of ecnoglutide.

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, ...

Researchers uncovered how estrogen heightens gut sensitivity in females by activating PYY-secreting L-cells, which stimulate ...

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...

A new study from Imperial has shown that the physical structure of food influences the hormones released as part of digestion ...

A model developed by LMU biophysicists demonstrates how biological processes form the convoluted internal architecture of the ...

RANKL/osteoprotegerin/RANK signaling regulates bone resorption ... antibodies to Dkk1 and sclerostin. Novel regulatory pathways linking fat mass, the CNS and the GI tract to the control of bone ...

To complement these single-protein assays, protein-protein interactions within signal transduction pathways show great promise as a new class of biomarker. Such interaction-based markers could be ...

Disruption of endocytosis in tumor cells induces Hedgehog pathway activation, which synergizes with the oncogene Yki to fuel tumor overgrowth and invasion. Tumors secrete Upd ligands, activating ...

A diabetes medication that lowers brain fluid pressure has cut monthly migraine days by more than half, according to a new ...