The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes. Here we report ...

In the GCGR 7TM crystal structure, this TM1 helical stalk is stabilized by the BRIL fusion protein and helix 8 of the adjacent symmetric unit (Supplementary Fig. 5) 4. No sequence coverage was ...

Based on the structures of GCGR-Gs and GCGR-Gi complexes, the scientists performed extensive functional studies using techniques such as mutagenesis, G protein activation and cell signaling to ...

Although GCGR couples to both G proteins through the common pocket, it does so with different interaction patterns, which account for G protein specificity. The measured interaction interface between ...

image: Structures of the human glucagon receptor GCGR involved in glucose homeostasis view more . Credit: Image by WU Beili's laboratory at SIMM. G protein-coupled receptors (GPCRs) are essential ...

"These results reported today represent the potential for a major advance in diabetes therapeutics. ISIS-GCGR Rx employs a unique mechanism to treat patients with type 2 diabetes. It is well known ...

Lanzhou University and Tencent Technology (Shenzhen) Co. Ltd. have patented glucagon receptor (GCGR) antagonists reported to be useful for the treatment of diabetes and hyperglycemia. Lanzhou ...