Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of ...

The fluorescein-labeled E166C mutant of the PenPC β-lactamase (E166Cf) represents a successful model in the construction of “switch-on” fluorescent biosensors from nonallosteric proteins (Chan P.-H.

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In a study of Salmonella enterica serovars, the acquisition of the IncB/O plasmid pH2332-166 via conjugation resulted in up to a 4096-fold increase in the minimal inhibitory concentration for ...

LYTENAVA™ is the first and only approved ophthalmic formulation of bevacizumab for the treatment of wet AMD in the European Union (EU) and United Kingdom (UK)2.8 million injections of repackaged ...

TOPLINE: For patients with beta-lactam allergy undergoing orthopedic surgery, prioritizing cefazolin as the preferred antibiotic for the prevention of surgical site infections (SSIs) did not lead ...

Figure 1. Infection by bacteriophage ΦStaph1N drives the loss of β-lactam resistance in MRSA. A. Schematic of the experimental setup. Drug-resistant (Abx R), phage-sensitive (Phage S) bacterial ...

Scynexis has resumed a trial of Brexafemme, triggering a $10M milestone payment from GSK and another $20 million due in six months, Scynexis says.