The glucose transporter GLUT4 ensures controlled glucose uptake into fat and muscle cells. By targeting several steps in the membrane trafficking of GLUT4, insulin signalling allows tight ...

GLUT4 is sequestered intracellularly in the absence of insulin, and is redistributed to the plasma membrane within minutes of insulin stimulation1,2.

Muscle GLUT4 content at baseline was similar between the groups. In the placebo group, 2 weeks of immobilization decreased GLUT4 content on an average of 22% (range -10 to -35%, P < 0.05).

Inside the cell, GLUT4 was contained in balloon-like structures known as vesicles. The vesicles transported GLUT4 to the cell membrane and merged with the membrane, a process known as fusion.

Stimulating glucose uptake by GLUT4 to treat type 2 diabetes. May 14, 2025. No Comments. Researchers at Daiichi Sankyo Co. Ltd. have developed a xanthene compound that can promote glucose uptake by ...

Finally, GLUT4 was visualized by an alkaline phosphatase-labeled antibody and quantified on a phosphoimager (STORM; Molecular Dynamics, Sunnyvale, CA). Data are means ± SE.