CHICAGO -- Neoadjuvant nivolumab (Opdivo) plus chemotherapy significantly improved overall survival (OS) compared with ...

Many of the components of this DNA replication apparatus associate with other cellular factors as components of multiprotein complexes, which act cooperatively in networks to regulate cell cycle ...

Checkpoint Therapeutics ... UNLOXCYT is a human immunoglobulin G1 monoclonal antibody that binds PD-L1 and blocks the interaction between PD-L1 and its T cell receptors, PD-1 and B7.1. This ...

and growth-inhibited cells were arrested in G 1 (Gibbons et al., 2000). In studies involving cancer cell lines growing in tissue culture, human prostate, breast, and small cell lung carcinomas ...

In the present study, we review approaches and studies that have shed some light on cardiomyocyte cell cycle regulation. For reference, an initial description of cardiomyogenic induction and ...

FRACTION-RCC: Innovative, high-throughput assessment of nivolumab + ipilimumab for treatment-refractory advanced renal cell carcinoma (aRCC). Biomarker analyses from the phase III CheckMate 214 trial ...

Here, we report that Pax3 and Pax7 binding protein 1 (Paxbp1) controls a key checkpoint during this critical transition. Deletion of Paxbp1 in adult MuSCs prevented them from reentering the cell cycle ...

Morbid sequelae include smooth muscle cell (SMC) hyperplasia and restenosis due to vascular neointima formation. Methods and Results In this study, we examined the inhibitory effects of a concentrated ...

njmu.edu.cn Background Clear cell renal cell carcinoma (ccRCC) is a malignant urogenital cancer with high mortality; however, current progress in understanding its molecular mechanism and predicting ...

The high-risk group was enriched in tumor progression pathways (like epithelial-mesenchymal transition, cell cycle checkpoints), exhibited low expression of immune checkpoint genes (BTLA, CD47), and ...

Contributed by Dinshaw J. Patel, January 6, 2021 (sent for review December 2, 2020; reviewed by Na Yang and Keqiong Ye) The Shieldin complex, composed of REV7, SHLD1, SHLD2, and SHLD3, protects DNA ...