It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that prepare it for the next phase. Cell cycle checkpoints are control mechanisms that ensure ...

CDKs function to phosphorylate many different proteins which are required for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the end of G1 and the ...

The G1–S transcriptional programme is robustly activated by positive feedback mechanisms, creating an 'all-or-none' switch that leads to cell cycle commitment. Inactivation of G1–S ...

The cell cycle is highly organised and divided into four phases (G1, S, G2 and M). Checkpoints are used to ensure that the important events of each stage are carried out before a cell can move ...

These stop the cell cycle at a checkpoint where the cell pauses to inspect its genome – G1/S – and corrects any mistakes before entering DNA synthesis. If the cell detects single-stranded breaks in ...

Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic ...

In addition to loss of the G1 checkpoint, some of the most common ... "Rather than merely reducing cell death and cell cycle arrest, loss of p53 reduced the level of DNA damage during DNA ...

The gene p21CIP1/WAF1 inhibits the proper functioning of cyclin-dependent kinases (CDKs), molecules that help to control cellular duplication. Although p21CIP1/WAF1 is known to be regulated by the ...