These drugs are known to act by targeting specific steps in the folate biosynthetic pathway, and their combined activity is far greater than the sum of their individual activities. For the last ...

These drugs are known to act by targeting specific steps in the folate biosynthetic pathway, and their combined activity is far greater than the sum of their individual activities. For the last ...

Advances have been made by upregulating key enzymes in the folate biosynthesis pathway, but challenges remain due to species-specific responses and the complex interaction of folate with cellular ...

‘There is an unrecognized cyclic pathway structure within the folate biosynthesis pathway in the drugs, that allows each drug to enhance the activity of the other.’ These drugs are known to ...