By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis—an ...

USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: ...

Scientists at the USC Leonard Davis School of Gerontology have discovered a key connection between high levels of iron in the ...

By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis-an ...

This damage is known as lipid peroxidation and it's a key feature of ferroptosis. Once lipid peroxidation starts, it quickly spreads to the cell's outer layer, damaging the main barrier and ...

The study reveals a significant relationship between elevated iron levels in the brain and greater cellular damage in individuals with both Down syndrome and Alzheimer’s disease.

These findings suggest that the damage in DSAD brains is driven by ferroptosis, a type of cell death linked to iron-induced lipid peroxidation. Thorwald explained that iron buildup leads to oxidative ...

More information: Max A. Thorwald et al. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis, Alzheimer's & Dementia (2025).