Itoh et al. 7 also crystallized a series of oxo fatty acids that bind helix 12 similarly to rosiglitazone, but whose keto group allows covalent binding of the ligand to Cys285 in helix 3 (Fig. 2c).

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Citrate is essential for the metabolism and development of neurons. A membrane transport protein called SLC13A5 plays a central role in this process ...