Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Example topics for Review Articles may include ... This collection of review articles explores recent advances and current understandings of somatic mutations acquired in human tissues during ...

As we age, our cells slowly accumulate random mutations in their genes, many of which are harmless. These are known as acquired or somatic mutations ... reveals a striking example of natural ...

Somatic mutations are genetic alterations that occur after conception. Unlike germline mutation, somatic mutations are not present in most body cells and develop sporadically, without a known family ...

The researchers acquired ... found one example of protection in the human esophagus. By middle age, many esophagus clones—often making up the bulk of esophagus tissue—have mutations disrupting ...

the founding director of the Human Genome Sequencing Center at Baylor College of Medicine, told me. “Maybe somatic mutations are the events that serve as the missing link.” James Bennett ...

For example, certain mutations are more common in people who smoke who develop lung cancer, while other mutations are often seen in never-smokers who develop the disease. Somatic gene mutations are ...

Quotient Therapeutics, a biotechnology company focused on studying the role of somatic mutations in disease, emerged from stealth Tuesday with $50 million from Flagship Pioneering. The company aims to ...

The mutation calling software include: sambamba, speedseq, varscan, shimmer, strelka, manta, lofreq_tar. It identifies somatic and germline variants from whole exome sequencing (WXS), RNA sequencing ...

Next, the team is working towards identifying other acquired mutations that might ... the Brain Somatic Mosaicism Network, the Psychiatric Genomics Consortium, the Allen Discovery Center for Human ...

Next, the team is working towards identifying other acquired mutations ... the Brain Somatic Mosaicism Network, the Psychiatric Genomics Consortium, the Allen Discovery Center for Human Brain ...

While some patients have inherited variants that you can find in a blood sample, about 90 percent of patients with vascular anomalies have acquired somatic mutations, or mutations that are not ...