News

Physician's Weekly14d
Breast Cancer Targeted Therapies and Guidelines, Part 2
Explore how cutting-edge agents like alpelisib, capivasertib, MEK and ERK inhibitors, and JAK inhibitors are reshaping the treatment landscape across subtypes.
Too Old to Operate19d
Breast Cancer Targeted Therapies and Guidelines, Part 1
mTOR inhibitor: Everolimus treats advanced or metastatic HR-positive/HER2-negative BC. Antibody-drug conjugates (ADCs): Sacituzumab govitecan treats TNBC and HR ...
Frontiers26d
Leveraging immune checkpoint inhibitors in lung cancer patients with pre-existing autoimmune disease: clinical insights, optimal timing, and predictive biomarkers for optimal ...
Recently, inhibitory ICs contribute to the immune escape of cancer cells and offer several therapeutic targets. Immune checkpoint inhibitors (ICIs), which target ICs, such as cytotoxic T-lymphocyte ...
eLife27d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
Crossing TRGL mice with a model of a neurodegenerative disease, the Q175 mouse model of HD, has enabled us to assess disease-related autophagy alterations in the Q175 and TRGL/Q175 models and their ...
C&EN28d
Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China Key Laboratory of New Drug ...
C&EN28d
Multicatalysis-Enabled Multicomponent Reactions Generate a PTP1B Inhibitor
Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China State Key Laboratory of Anti-Infective Drug Discovery ...