Lung cancer is the leading cause of cancer-related mortality worldwide. 1,2 Non–small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases, with a 5-year survival rate of ...

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor–Resistant Disease Kadoaki Ohashi , Yosef E. Maruvka , Franziska Michor , William Pao Journal of Clinical Oncology 2013 31: 8 , 1070-1080 ...

Clinicopathologic features of histologic transformation in lung adenocarcinoma after treatment with epidermal growth factor receptor-tyrosine kinase inhibitors, Annals of Diagnostic Pathology, 77 ...

Most patients with non–small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of ...

The epidermal growth factor receptor (EGFR) is a target found in high concentrations in several solid tumors including lung, breast, colorectal, and brain. Tyrosine kinase inhibitors, such as ...

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

Tarceva (Roche/Chugai/Astellas) Drug Outlook Report to 2026: An Orally Available Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor - ResearchAndMarkets.com July 05, 2019 07:48 AM ...

Epidermal growth factor receptor, also known as EGFR, is a biomarker frequently implicated in cancer and EGFR-TKIs are a class of drugs commonly used to target EGFR and treat the disease.

HR-positive/HER2-negative is the most common subtype of breast cancer in women. HR-positive/HER2-negative metastatic breast ...

Activation of the epidermal growth factor receptor (EGFR) has been linked to tumour proliferation, invasion, metastasis and angiogenesis in epithelial tumours. Inhibitors of the EGFR have emerged ...

Epidermal growth factor receptor (EGFR) is a protein tyrosine kinase which plays a crucial role in signal transduction pathways that regulate key cellular functions such as survival and proliferation.