IL-5 was able to stimulate colony formation but the colonies did not contain eosinophils; most were composed of blast cells and the remainder of neutrophilic granulocytes. Surprisingly ...

Granulocytes are classified into 3 more distinct types: neutrophils, eosinophils, and basophils, according to the histologic staining reactions of the intracellular granules. Neutrophils are the ...

Approaches to treatment vary based on inflammatory phenotype. Peripheral eosinophil counts may help guide treatment decisions similar to their use in chronic obstructive pulmonary disease ...

Please provide your email address to receive an email when new articles are posted on . Tezepelumab has received an FDA breakthrough therapy designation as a maintenance treatment for patients ...

The acute phase of inflammation is characterized by the rapid influx of blood granulocytes, typically neutrophils, followed swiftly by monocytes that mature into inflammatory macrophages that ...

1 Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama, USA 2 Department of Medicine IV, Division Gastroenterology and Hepatology, Medical University ...

Asthma presents as a heterogeneous disease. In typical Th2-type allergic asthma, interleukin (IL)-4 and IL-13 predominate, driving IgE production and recruitment of eosinophils into the lungs. Chronic ...

Mepolizumab is the only approved biologic evaluated in patients with an eosinophilic phenotype characterised by a blood eosinophil count (BEC) threshold as low as ≥150 cells/µL. BEC is captured by a ...

We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled ...

yahoo.com Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value ...

Granulocytes were enriched from the erythrocyte pellet by consequent dextrane sedimentation (60 min, 1 %, Carl Roth, Germany). The purity of neutrophil isolations was routinely above 90 %. Murine ...