Protein folding is justly renowned for its combinatorial complexity: not only is it driven by a wide range of different and often competing interactions, but there are hundreds or even thousands of ...

The protein homeostasis (proteostasis) network (Balch et al, 2008), consisting of a collection of molecular chaperones, ...

It is controversial whether fast-folding proteins can form productive on-pathway intermediates that are more stable than the denatured state because noncovalent intermediates are usually evanescent.

The company has already used its protein-folding AI, AlphaFold, to generate structures for the human proteome, as well as yeast, fruit flies, mice, and more. Back in December 2020, DeepMind took the ...

This is a preview. Log in through your library . Abstract The B domain of staphylococcal protein A (BdpA) is a small helical protein that has been studied intensively in kinetics experiments and ...