We hypothesized that ET-1–induced PVAT and vascular oxidative stress and inflammation contribute to the progression of atherosclerosis and increased incidence of AAAs. To test this hypothesis, we ...

The Mattei Plan - a shared pathway to boost development across Africa - in spotlight at African Development Bank Group’s 2025 Annual Meetings Amba Mpoke-Bigg, Communication and External Relations ...

1 Department of Cell Systems and Anatomy, The University of Texas Health San Antonio, San Antonio, TX, United States 2 Department of Obstetrics, The Second Xiangya Hospital, Central South University, ...

Here, we demonstrate that inhibition of the p38 MAPK-MK2 signaling pathway sensitizes cancer cells to MTA treatment. We utilize CMPD1, a dual-target inhibitor, to concurrently suppress the p38-MK2 ...

while pathways pertaining to collagen synthesis and extracellular matrix organization were upregulated. These findings and the altered bioenergetic profile indicative of mitochondrial dysfunction ...

The present study demonstrates that chronic blockade of endothelin receptors is associated with an early and sustained increase of ischemia-induced angiogenesis in vivo and that this effect is ...

Roche Colorado Corporation, Boulder Technology Center, 2075 North 55th Street, Boulder, Colorado 80301, U.S.A. Article Views are the COUNTER-compliant sum of full text article downloads since November ...

By addressing this shared pathway, interventions could mitigate neurovascular ... to mitigate neuroinflammation-induced astrocytic endothelin-1 overproduction, which disrupts capillary perfusion; (3) ...

In an interview last month with former Fox News journalist Megyn Kelly, Makary unveiled plans for a new regulatory pathway for rare disease drugs, allowing for their conditional approval based on a ...

Endothelin (ET) is a recently discovered 21-amino acid peptide that has potent physiologic and pathophysiologic effects that appear to be involved in the development of heart failure. These ...