We hypothesized that ET-1–induced PVAT and vascular oxidative stress and inflammation contribute to the progression of atherosclerosis and increased incidence of AAAs. To test this hypothesis, we ...

Substantial combination benefit of targeting both the ANGPT2 and VEGFA pathways has been demonstrated preclinically. Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and ...