Erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the ...

Established in 2017, the International Player Pathway program provides players born outside the United States greater opportunity to seek an NFL roster spot. Though he originally agreed to a sign ...

Given the significant increase in joint pain and osteoarthritis in patients after COVID infection, this research points to a novel therapeutic pathway, positioning endothelin receptor blockers as a ...

Drugs targeting the three traditional treatment pathways (nitric oxide, endothelin, and prostacyclin) significantly increased 6-minute walk distance (6MWD) and reduced the likelihood of clinical ...

“Since the endothelin pathway was not yet tackled in these patients, we selected aprocitentan, an endothelin receptor antagonist with the ideal properties for use in this condition. We were ...

1 Department of Physiology, School of Medicine, Yanbian University, Yanji, China. 2 Institue of Clinical Medicine, Yanbian University, Yanji, China. 3 Key Laboratory of Organism Functional Factors of ...

From the Departments of Pharmacology (F.-P.X., Q.Y., S.-B.L., J.-D.L.) and Internal Medicine (M.-S.C.), Guangzhou Medical College, Guangzhou, China; the Department of ...

Three main pathways (prostanoids, nitric oxide and endothelin) are currently used as a therapeutic target for the treatment of patients with different groups of PH. However, drugs targeting these ...

“I would argue that leaves one very important system still unopposed and that is the endothelin pathway. Indeed, endothelin has clearly been implicated in the pathogenesis of hypertensio ...

Schlaich said the endothelin pathway has been previously “implicated in the pathogenesis of hypertension,” particularly in sodium and water retention; the endothelin A and B receptors exert their ...