Obesity significantly impacts cardiovascular health, increasing risks such as left ventricular hypertrophy, atherosclerosis, ...

Analysts at Leerink Partnrs lifted their FY2026 earnings estimates for Travere Therapeutics in a research report issued to ...

drug is an antagonist of both endothelin type A (ETA) and angiotensin II subtype 1 (AT1) receptors, which are associated with progression of kidney disease. It's in late-stage development for IgA ...

Figure 1. Established vasomotor pathways targeted by current and emerging therapies in PAH. The 3 major pathways (endothelin-1, nitric oxide, and prostacyclin) involved in the regulation of pulmonary ...

endothelin-1; IL-6, interleukin 6; and TGF-β, transforming growth factor-β. Taken together, cardiac remodeling is a sophisticated pathophysiological process in HF and involves many types of cells, ...

The fourth line of treatment for patients with resistant hypertension should include mineralocorticoid receptor antagonists such as spironolactone, as demonstrated in the PATHWAY-2 trial ... and dual ...

(2009) Endothelin-1 and trans- forming growth fac-tor-beta1 independently ... (2008) Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Molecular and ...

Key cardiogenic signaling pathways, including ACTIVIN ... and increased myofibrillar disarray upon treatment with endothelin-1 (EDN1). Electrophysiological assessments revealed a tachyarrhythmic ...

Hope is not passive wishing but an active, dynamic process. According to Hope Theory, hope involves two components: agency and pathways. Agency is the belief in one’s capability to act ...