Schlaich said the endothelin pathway has been previously “implicated in the pathogenesis of hypertension,” particularly in sodium and water retention; the endothelin A and B receptors exert their ...

Experimental & Molecular Medicine - Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway Skip to main content Thank you for visiting ...

Charles D. Burger, MD: The FDA-approved therapies for pulmonary arterial hypertension [PAH] target 1 of 3 pathways. Endothelin, more specifically endothelin-1, is produced by the body and causes ...

The first, dual endothelin receptor antagonist aprocitentan, acts by targeting the endothelin pathway implicated in hypertension. It lowered systolic BP after 4 weeks in the phase III, placebo ...

Aprocitentan, a dual endothelin antagonist, was superior to placebo for BP lowering and was well tolerated in patients with resistant hypertension. Source: Adobe Stock Targeting the endothelin pathway ...

These findings suggest a potentially transformative approach for the treatment of glaucoma by targeting the endothelin pathway, a well-established mediator of vascular dysfunction in the disease.