Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to ...

The recent focus on mesenchymal stem cells (MSCs) has generated enthusiasm due to their unique regenerative and immunomodulating properties, including the ability to reverse fibrosis 6, 7. Recent ...

Epithelial cellular adhesion molecules (EpCAM), highly expressed antigens on cancer cell surfaces, are crucial biomarkers for tumor diagnosis and therapy. Despite its utility, the efficiency of ...

Epithelial-to-mesenchymal transition (EMT), a complex biological pathway that facilitates cellular plasticity, is used by tumor cells to enable metastasis and drug resistance. Our functional ...

How endothelial cells sense and respond to dynamic changes in their biophysical surroundings as we age is not fully understood. Vascular stiffness is clearly a contributing factor not only in several ...

Background: Aberrant epithelial repair is a key event in the airway remodelling which characterises obliterative bronchiolitis (OB) in the transplanted lung. The potential for airway epithelium from ...

Endothelial-to-mesenchymal transition (EndMT) was modeled in hPAECs by treating with transforming growth factor-β, tumor necrosis factor-α, and interleukin-1β in combination. Results: In rats with MCT ...