Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

In non-pregnant individuals with diabetes, similar vascular changes are attributed to disruptions in endothelial-to-mesenchymal transition (EndMT), a key process where endothelial cells adopt a ...

The novel anthraquinone compound Kanglexin prevents endothelial-to-mesenchymal transition in atherosclerosis by activating FGFR1 and suppressing integrin β1/TGFβ signaling ...

The approval was based on data from the multicenter, prospective, single-arm MSB-GVHD-001 study (ClinicalTrials.gov Identifier: NCT02336230), which evaluated remestemcel-L, an allogeneic bone ...

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining ...

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells ...

Citation: Acetate controls endothelial-to-mesenchymal transition: Potential therapeutic target for reducing atherosclerosis (2023, June 19) retrieved 23 May 2025 from https://medicalxpress.com ...

Oncotarget published "Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth" which reported that the authors ...

Endothelial-to-mesenchymal transition (EndMT) was first described in the endocardial cushions of the embryonic heart by Markwald et al 1,2 in the mid-1970s. For decades this endothelial transition was ...

Endothelial to mesenchymal transition (EndMT) is a complex cellular transdifferentiation process whereby endothelial cells (EC) lose their endothelial identity and acquire mesenchymal cell ...

1 Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands; 2 Oncode Institute, Leiden University Medical Center, Leiden, Netherlands; Endothelial-to-mesenchymal ...