PTC-specific p300 mediates the endothelial-mesenchymal transition in renal fibrosis development Given the physiological importance of p300 in renal fibrosis, we sought to determine the molecular ...

Gestational diabetes mellitus (GDM) is linked to altered fetal development and an increased risk of offspring developing cardiometabolic diseases in adulthood. The mechanisms responsible are unclear; ...

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining ...

Endothelial-mesenchymal transition (EndoMT) plays a key role in tumor progression and metastasis. However, the underlying mechanism and characteristics of cells in different EndoMT phases remain ...

Endothelial-to-mesenchymal transition in cardiovascular disease Endothelial-to-mesenchymal transition (EndMT) is a process through which endothelial cells (ECs) transition into mesenchymal cells and ...

In a new study, researchers including Yale School of Medicine's Michael Simons, MD, identify the molecular underpinnings of persistent endothelial-to-mesenchymal transition (EndMT), an important ...

Graphical Abstract Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells suppress constituent endothelial properties and take on mesenchymal cell behaviors. To begin ...

Endothelial-mesenchymal transition (EndMT) is known to play a role in HO, and our recent study observed that neuroendocrine signals can promote HO by modulating EndMT. Melatonin, a neuroendocrine ...

Abstract Endothelial cells play an important role in maintenance of the vascular system and the repair after injury. Under proinflammatory conditions, endothelial cells can acquire a mesenchymal ...