This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is convincing and the ...

This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is mostly convincing, ...

As a complementary approach, MTACs harness the M6P receptor and work by degrading pathogenic proteins in the endolysosome of M6PR-expressing cells, which include hepatocytes but also encompass ...

As a complementary approach, MTACs harness the M6P receptor and work by degrading pathogenic proteins in the endolysosome of M6PR-expressing cells, which include hepatocytes but also encompass ...

This stunts calcium flow from the ER to lysosomes, stalling the cellular waste disposal system. Knocking out APP normalizes endolysosome function. Scientists praised the research. “This is beautiful ...

At the endolysosome membrane, CD151 links VCP/p97 to (1) IFITM3 (interferon-induced transmembrane protein 3), which regulates multivesicular body functions, to restrain IFITM3-mediated exosomal ...

In its late phase, the endosome merges with lysosomes that contain enzymes, forming an endolysosome. Within this structure, the enzymes break down both material from the body and foreign material.

ATACs work by shuttling pathogenic proteins from circulation into the endolysosome where the unwanted proteins are degraded. The presentation will showcase new ATAC mechanism of action studies ...

"We are trying to image this process and trying to track the whole changing process of the endolysosome and trying to figure out in which state and which location these endolysosomes will become ...

“We are trying to image this process and trying to track the whole changing process of the endolysosome and trying to figure out in which state and which location these endolysosomes will become ...