The CXorf21 protein product, known as TASL, binds SLC15a4, another gene with SLE- risk alleles, on the surface of the endolysosome. Methods We used CRIPR-Cas to knock down expression of CXorf21 (TASL) ...

Fig. 3. CHMP5 controls skeletal progenitor cell senescence. (A) Cell number counting and AlamarBlue assay determining cell proliferation in Chmp5 Ctsk and Chmp5 Ctsk/+ periskeletal progenitors from ...

Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas this may initiate disease in familial cases, onset in sporadic diseases may originate from a gradually disrupted ...

Edited by Janet R. Sparrow, Columbia University, New York, NY, and accepted by Editorial Board Member Jeremy Nathans October 13, 2018 (received for review February 9, 2018) To estimate the relative ...

Contributed by J. Wade Harper; received September 23, 2024; accepted October 30, 2024; reviewed by Pietro V. De Camilli and Michael Lazarou This contribution is part of the special series of Inaugural ...

Christy Hung is a Race Against Dementia Fellow and Alzheimer's Research UK Senior Fellow at UCL and the Francis Crick Institute. My research interests and expertise revolve around leveraging human ...

† Laboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang ...

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IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m 6 A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.