In this article, we focus on probe drugs lacking significant metabolism to highlight mechanisms of interactions of selected intestinal, hepatic and renal drug transporters (e.g., organic anion ...

Membrane drug transporters have been identified as a determinant of drug disposition in the body, potentially affecting absorption, pharmacokinetics, drug-drug interactions, and safety profiles ...

The team found drug transporters for over 20 medications and used this data along with data from external medication databases to train an AI machine-learning model that could predict drugs that ...

Example 1: Cross-species comparison of drug handling of PAH excretion in the kidney transporter model Para-aminohippurate (PAH), a derivative of hippuric acid, is used to measure renal plasma flow.

DNA 'Nanotransporters' to treat cancer Date: November 2, 2022 Source: University of Montreal Summary: Chemists specializing in nanotechnology draw inspiration from nature to create molecular ...

When they used pig tissue to test their machine learning model on 50 approved and investigational drugs, they identified 58 previously unknown drug-transporter interactions and 1,810,270 unknown ...

The findings, published in Cell, have implications for drug development. Transporters escort substances across the cell membrane so that they can carry out their functions. Sphingosine-1-phosphate ...

Advanced drug screening: A microphysiological system to assess drug transport and nephrotoxicity. Your friend's email. Your email. I would like to subscribe to Science X Newsletter.

The liver is a major contributor to first-pass elimination of orally administered drugs as well as for plasma clearance of systemically distributed drugs. The amount of blood filtered by the liver ...