In this article, we focus on probe drugs lacking significant metabolism to highlight mechanisms of interactions of selected intestinal, hepatic and renal drug transporters (e.g., organic anion ...

Membrane drug transporters have been identified as a determinant of drug disposition in the body, potentially affecting absorption, pharmacokinetics, drug-drug interactions, and safety profiles ...

the team had to first identify the drug transporters. In pharmacokinetics, the study of the absorption, distribution, metabolism, excretion, and toxicity of medication, drug transporters are ...

This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity. The paper is published in the ...

Example 1: Cross-species comparison of drug handling of PAH excretion in the kidney transporter model Para-aminohippurate (PAH), a derivative of hippuric acid, is used to measure renal plasma flow.

Chemists specializing in nanotechnology draw inspiration from nature to create molecular transporters that optimize the release of therapeutic drugs. A team of Canadian researchers from ...

located on the presynaptic membrane can transport NA into presynaptic neurons. In clinical applications, various small molecule drugs inhibit NET to increase the concentration of NA in the ...

The liver is a major contributor to first-pass elimination of orally administered drugs as well as for plasma clearance of systemically distributed drugs. The amount of blood filtered by the liver ...

The team found drug transporters for over 20 medications and used this data along with data from external medication databases to train an AI machine-learning model that could predict drugs that ...

Advanced drug screening: A microphysiological system to assess drug transport and nephrotoxicity. Your friend's email. Your email. I would like to subscribe to Science X Newsletter.